List of publications – December 2021

 

Prof. Judith Berman

 

• Aneuploidy Underlies Tolerance and Cross-Tolerance to Drugs in Candida parapsilosis.

Yang F, Lu H, Wu H, Fang T, Berman J, Jiang YY. Microbiol Spectr. 2021 Oct 6:e0050821. doi: 10.1128/Spectrum.00508-21. Online ahead of print. PMID: 34612700

• Adaptation to Fluconazole via Aneuploidy Enables Cross-Adaptation to Amphotericin B and Flucytosine in Cryptococcus neoformans.

Yang F, Gritsenko V, Lu H, Zhen C, Gao L, Berman J, Jiang YY. Microbiol Spectr. 2021 Sep 29:e0072321. doi: 10.1128/Spectrum.00723-21. Online ahead of print. PMID: 34585947

• Adaptive Resistance Mutations at Suprainhibitory Concentrations Independent of SOS Mutagenesis.

Gutiérrez R, Ram Y, Berman J, de Sousa KCM, Nachum-Biala Y, Britzi M, Elad D, Glaser G, Covo S, Harrus S. Mol Biol Evol. 2021 Sep 27;38(10):4095-4115. doi: 10.1093/molbev/msab196. PMID: 34175952

• Multifactorial Mechanisms of Tolerance to Ketoconazole in Candida albicans.

Xu Y, Lu H, Zhu S, Li WQ, Jiang YY, Berman J, Yang F. Microbiol Spectr. 2021 Sep 3;9(1):e0032121. doi: 10.1128/Spectrum.00321-21. Epub 2021 Jun 23. PMID: 34160280

 

 

Prof. Marcelo Ehrlich

• Genomic Analysis Illustrated a Single Introduction and Evolution of Israeli Bluetongue Serotype 8 Virus Population 2008-2019.

Golender N, Eldar A, Ehrlich M, Kenigswald G, Shlamovitz I, Even-Tov B, Zamir L, Klement E, Bumbarov V. Microorganisms. 2021 Sep 14;9(9):1955. doi: 10.3390/microorganisms9091955. PMID: 34576850

 

Prof. Orna Elroy-Stein

• The Energy Status of Astrocytes Is the Achilles' Heel of eIF2B-Leukodystrophy.

Herrero M, Daw M, Atzmon A, Elroy-Stein O. Cells. 2021 Jul 22;10(8):1858. doi: 10.3390/cells10081858. PMID: 34440627

• Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration.

Cleveland A, Romero A, Azcona LA, Herrero M, Nikolova V, Moy S, Elroy-Stein O, Gama V, Gershon T.

Cell Death & Disease. 2021 In Press.

 

 

Prof. Gideon Fleminger

• Potential neurotoxicity of titanium implants: Prospective, in-vivo and in-vitro study.

Shelly S, Liraz Zaltsman S, Ben-Gal O, Dayan A, Ganmore I, Shemesh C, Atrakchi D, Garra S, Ravid O, Rand D, Israelov H, Alon T, Lichtenstein G, Sharabi S, Last D, Gosselet F, Rosen V, Burstein G, Friedlander A, Harel R, Vogel G, Schnaider Beeri M, Mardor Y, Lampl Y, Fleminger G, Cooper I. Biomaterials. 2021 Sep;276:121039. doi: 10.1016/j.biomaterials.2021.121039. Epub 2021 Jul 24. PMID: 34352627

 

Prof. Ehud Gazit

 

• Metal Organic Spin Transistor.

Goren N, Das TK, Brown N, Gilead S, Yochelis S, Gazit E, Naaman R, Paltiel Y. Nano Lett. 2021 Oct 27;21(20):8657-8663. doi: 10.1021/acs.nanolett.1c01865. Epub 2021 Oct 18. PMID: 34662128

 

• Expanding the Structural Diversity and Functional Scope of Diphenylalanine-Based Peptide Architectures by Hierarchical Coassembly.

Ji W, Tang Y, Makam P, Yao Y, Jiao R, Cai K, Wei G, Gazit E. J Am Chem Soc. 2021 Oct 27;143(42):17633-17645. doi: 10.1021/jacs.1c07915. Epub 2021 Oct 14. PMID: 34647727

 

• Cytokinin Inhibits Fungal Development and Virulence by Targeting the Cytoskeleton and Cellular Trafficking.

Gupta R, Anand G, Pizarro L, Laor D, Kovetz N, Sela N, Yehuda T, Gazit E, Bar M. mBio. 2021 Oct 26;12(5):e0306820. doi: 10.1128/mBio.03068-20. Epub 2021 Oct 19. PMID: 34663100

 

• Kinetic and Thermodynamic Driving Factors in the Assembly of Phenylalanine-Based Modules.

Zaguri D, Zimmermann MR, Meisl G, Levin A, Rencus-Lazar S, Knowles TPJ, Gazit E. ACS Nano. 2021 Oct 25. doi: 10.1021/acsnano.1c07537. Online ahead of print. PMID: 34694771

• Metabolite assemblies: A surprising extension to the amyloid hypothesis.

Gour N, Gazit E. Curr Opin Chem Biol. 2021 Sep 2;64:154-164. doi: 10.1016/j.cbpa.2021.07.005. Online ahead of print. PMID: 34482124

 

 

Prof. Uri Gophna

• Specific Changes in the Mammalian Gut Microbiome as a Biomarker for Oxytocin-Induced Behavioral Changes.

Dangoor I, Stanić D, Reshef L, Pešić V, Gophna U. Microorganisms. 2021 Sep 12;9(9):1938. doi: 10.3390/microorganisms9091938. PMID: 34576833

 

 

Prof. Martin Kupiec

• Split Chloramphenicol Acetyl-Transferase Assay Reveals Self-Ubiquitylation-Dependent Regulation of UBE3B.

Levin-Kravets O, Kordonsky A, Shusterman A, Biswas S, Persaud A, Elias S, Langut Y, Florentin A, Simpson-Lavy KJ, Yariv E, Avishid R, Sror M, Almog O, Marshanski T, Kadosh S, Ben David N, Manori B, Fischer Z, Lilly J, Borisova E, Ambrozkiewicz MC, Tarabykin V, Kupiec M, Thaker M, Rotin D, Prag G. J Mol Biol. 2021 Sep 29;433(23):167276. doi: 10.1016/j.jmb.2021.167276. Online ahead of print. PMID: 34599943

 

Prof. Gerardo Lederkremer

• The Sigma-1 receptor is an ER-localized type II membrane protein.

Sharma N, Patel C, Shenkman M, Kessel A, Ben-Tal N, Lederkremer GZ. J Biol Chem. 2021 Oct 11:101299. doi: 10.1016/j.jbc.2021.101299. Online ahead of print. PMID: 34648767

 

Dr. Vered Padler-Karavani

• Sulfation Code and Conformational Plasticity of l-Iduronic Acid Homo-Oligosaccharides Mimic the Biological Functions of Heparan Sulfate.

Shanthamurthy CD, Gimeno A, Leviatan Ben-Arye S, Kumar NV, Jain P, Padler-Karavani V, Jiménez-Barbero J, Kikkeri R. ACS Chem Biol. 2021 Sep 29. doi: 10.1021/acschembio.1c00582. Online ahead of print. PMID: 34586794

 

Prof. Dan Peer

• Therapeutic inhibitory RNA in head and neck cancer via functional targeted lipid nanoparticles.

Kampel L, Goldsmith M, Ramishetti S, Veiga N, Rosenblum D, Gutkin A, Chatterjee S, Penn M, Lerman G, Peer D, Muhanna N. J Control Release. 2021 Sep 10;337:378-389. doi: 10.1016/j.jconrel.2021.07.034. Epub 2021 Jul 23. PMID: 34303750

• Conformation-sensitive targeting of lipid nanoparticles for RNA therapeutics.

Dammes N, Goldsmith M, Ramishetti S, Dearling JLJ, Veiga N, Packard AB, Peer D. Nat Nanotechnol. 2021 Sep;16(9):1030-1038. doi: 10.1038/s41565-021-00928-x. Epub 2021 Jun 17. PMID: 34140675

 

 

Prof. Tal Pupko

• A probabilistic model for indel evolution: differentiating insertions from deletions.

Loewenthal G, Rapoport D, Avram O, Moshe A, Wygoda E, Itzkovitch A, Israeli O, Azouri D, Cartwright RA, Mayrose I, Pupko T. Mol Biol Evol. 2021 Sep 1:msab266. doi: 10.1093/molbev/msab266. Online ahead of print. PMID: 34469521

 

 

 

Prof. Daniel Segal

 

• Glycans to improve efficacy and solubility of protein aggregation inhibitors.

Paul A, Segal D, Zacco E. Neural Regen Res. 2021 Nov;16(11):2215-2216. doi: 10.4103/1673-5374.310688. PMID: 33818499

 

• Inhibition of tau amyloid formation and disruption of its preformed fibrils by Naphthoquinone-Dopamine hybrid.

Paul A, Viswanathan GK, Huber A, Arad E, Engel H, Jelinek R, Gazit E, Segal D. FEBS J. 2021 Jul;288(14):4267-4290. doi: 10.1111/febs.15741. Epub 2021 Feb 18. PMID: 33523571

 

• Dual concentration-dependent effect of ascorbic acid on PAP(248-286) amyloid formation and SEVI-mediated HIV infection.

Mohapatra S, Viswanathan GKK, Wettstein L, Arad E, Paul A, Kumar V, Jelinek R, Münch J, Segal D. RSC Chem Biol. 2021 Aug 10;2(5):1534-1545. doi: 10.1039/d1cb00084e. eCollection 2021 Oct 7. PMID: 34704058

 

• Amyloidogenic Properties of Peptides Derived from the VHL Tumor Suppressor Protein.

Kumar V, Viswanathan GKK, Ralhan K, Gazit E, Segal D. ChemMedChem. 2021 Aug 25. doi: 10.1002/cmdc.202100441. Online ahead of print. PMID: 34431623

 

 

Prof. Adi Stern

• Unraveling a Nosocomial Outbreak of COVID-19: The Role of Whole-Genome Sequence Analysis.

Meijer SE, Harel N, Ben-Ami R, Nahari M, Yakubovsky M, Oster HS, Kolomansky A, Halutz O, Laskar O, Henig O, Stern A, Paran Y. Open Forum Infect Dis. 2021 Mar 12;8(10):ofab120. doi: 10.1093/ofid/ofab120. eCollection 2021 Oct. PMID: 34631912

 

 

Prof. Miguel Weil

• ATP-citrate lyase promotes axonal transport across species.

Even A, Morelli G, Turchetto S, Shilian M, Bail RL, Laguesse S, Krusy N, Brisker A, Brandis A, Inbar S, Chariot A, Saudou F, Dietrich P, Dragatsis I, Brone B, Broix L, Rigo JM, Weil M, Nguyen L. Nat Commun. 2021 Oct 7;12(1):5878. doi: 10.1038/s41467-021-25786-y. PMID: 34620845

 

• Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism.

Kakhlon O, Vaknin H, Mishra K, D'Souza J, Marisat M, Sprecher U, Wald-Altman S, Dukhovny A, Raviv Y, Da'adoosh B, Engel H, Benhamron S, Nitzan K, Sweetat S, Permyakova A, Mordechai A, Akman HO, Rosenmann H, Lossos A, Tam J, Minassian BA, Weil M. EMBO Mol Med. 2021 Oct 7;13(10):e14554. doi: 10.15252/emmm.202114554. Epub 2021 Sep 6. PMID: 34486811